About refudiate and the noninferiority of MACCE

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The study I just reviewed (SYNTAX 3 Analysis) had a couple of words that I would like to talk to you about. The first one is “noninferiority“. In the age of “refudiate“, it should be no surprise that new words arrive every now and then, but “noninferiority”?  In SYNTAX it refers to an attempt to prove that in this study, …

SYNTAX 3 Analysis

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At the September meeting of the European Association for Cardio-Thoracic Surgery Meeting three year follow-up data of the SYNTAX trial [9] were presented. I have commented repeatedly on both SYNTAX and reactions it provoked in the professional literature and the lay press [4], [5], [6],[7],[8]. In this analysis, the SYNTAX score was used to separate patients into three groups. This …