Antiplatelet Drugs, Prevention and Treatment of Arterial Thrombosis

Posted on May 4, 2010 - 3:23pm

Current guidelines support dual antiplatelet therapy with aspirin and clopidogrel (Plavix) in a number of clinical scenarios:

  • ST-segment-elevation myocardial infarction (SEMI),
  • Non-ST-elevation MI,
  • Percutaneous Coronary Intervention.

Modify the Risk of Non-Cardiac Operations

Physicians are often asked to estimate the risk for peri-operative myocardial infarction or cardiac death in patients being considered for non-cardiac surgery. Almost 30 million patients undergo noncardiac surgery annually in the United States; about one third have known coronary artery disease or risk factors for atherosclerosis.

The 500 000 patients who undergo peripheral vascular procedures each year are thought to have a particularly high risk for perioperative cardiac events.

Major Cardiac Event Rates by Cardiac Risk Index (3)


Event Rate (95% CI), %